Since opening in 2005, this hotel has been refining the concept of luxury, retaining the detail-oriented service focus, but removing any hints of stodginess. Rooms feature stylish contemporary décor in creams and dark woods, with standard features such as flat-screen TVs, crisp Pratesi linens and deep bathtubs that may inspire you to order from the hotel’s Signature Bath menu. The in-house Rèmede Spa is the pinnacle of extravagant pampering, while the ground-floor restaurant, Ame, offers Japanese-influenced fare. When you go out, the staff will be happy to shuttle you to your destination—in a Bentley, of course.

The St. Regis San Francisco Amenities:

• 260 & 46 suite rooms, 40 story. Pets accepted, under 20 lbs; $25 Fee. Check-in 3 pm, check-out Noon. High-speed Internet access, wireless Internet access. 3 restaurants, bar. Fitness room, fitness classes available, spa. Indoor pool, whirlpool. Business center.